12/1/2022 0 Comments Type o negative chickenIt was reported that the AA at position 394 in VP1 was a major genetic determinant of virulence. Molecular characterization of the CAV genome revealed that the VP1 protein had a hypervariable region (positions 139–151) ( 6). VP1 is the major viral structural protein playing a critical role in viral growth and spread, while VP2 is a scaffold protein that in combination with VP1 generates neutralizing epitopes ( 4, 5). #Type o negative chicken fullThe full length of CAV genome consists of 2,298 or 2,319 nucleotides, which contains three overlapping open reading frames (ORFs), and encodes viral protein 1 (VP1, ORF1, 52 kDa), VP2 (ORF2, 24 kDa), and VP3 (ORF3, 13 kDa) proteins respectively ( 2, 3). These findings enrich the epidemiological data on CAV and may provide information for preventing its further spread in Yunnan province, China.Ĭhicken anemia virus (CAV) is a member of the genus Gyrovirus, which is a non-enveloped, icosahedral single-stranded DNA virus ( 1). Besides, CAV infection caused a sharp decrease in chicken body weight and immune organ indices including the ratio of thymus or bursa to body weight at 21 dpi, which displayed the potential immunosuppression state at this stage. CAV infection induced severe anemia with significant decrease in packed cell volume (PCV), and serious atrophy and lesion of thymus and bursa with high viral load at 14 dpi. The mean death time of infected chickens was 13.1 days post infection (dpi). Moreover, the animal infection experiments further confirmed that the strain YN04 is a highly pathogenic strain, which can cause 86.67% mortality in chickens in the infection group. In this study, a CAV strain YN04 belonging to genotype A was first identified from infected chickens in Yunnan province, China. National and Regional Joint Engineering Laboratory for Medicament of Zoonosis Prevention and Control, Guangdong Provincial Key Laboratory of Zoonosis Prevention and Control, College of Veterinary Medicine, South China Agricultural University, Guangzhou, ChinaĬhicken anemia virus (CAV), which has been reported in many countries, causes severe anemia and immunosuppression in chickens.Manman Dai * †, Yuwen Huang †, Lin Wang, Jing Luo, Nan Yan, Lin Zhang, Haoqi Huang, Jie Zhou, Ziwei Li and Chenggang Xu *
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